Amelioration of Lead-induced Toxicity in Blood, Liver and Kidney Tissues of Male Wistar Rats by Fermented Ofada Rice

Authors

  • Eferhire Aganbi Department of Biochemistry, Faculty of Science, P.M.B 1 Delta State University Abraka
  • Oghenetega Jonathan Avwioroko African Research Laboratories Otorho-Agbon, Delta State Nigeria
  • Emmanuel Rex Enabulele Department of Biochemistry Delta State University
  • Onyeka Joshua Osagu Department of Biochemistry Delta State University
  • Chinedu Kennis Uwandu Biochemistry, Delta State University
  • Assumpta Ike Biochemistry, Delta State University
  • Aaron Akpede Biochemistry, Delta State University
  • Prince Eferusuoa Biochemistry, Delta State University

DOI:

https://doi.org/10.24925/turjaf.v3i9.754-759.436

Keywords:

Ofada rice, Lead-induced toxicity, Total flavonoids, Antioxidants FRAP assay

Abstract

The protective effects of ‘ofada‘ rice koji (ORK, fermented ofada rice) and ascorbic acid (AA) against lead (Pb)-induced toxicity in the blood, liver and kidney tissues of male Wistar rats was investigated. The animals were divided into four treatment groups (A – D, n = 5). Groups B, C and D were intoxified by intra-peritoneal injection of 75 mg lead acetate/kg body weight. Groups C and D only had their feed mixed with ORK and AA, respectively. The results showed no significant difference in % packed cell volume (PCV) and Pb concentrations. Feeding with ORK and AA significantly decreased alanine aminotransferase activities (36.50 ± 3.54 and 34.02 ± 0.05 UL-1 respectively) compared to Pb-only treated group (85.50 ± 3.25 UL-1). The ferric reducing antioxidant power (FRAP) for organs increased significantly following intake of feeds mixed with ORK and AA; increases in FRAP was higher for ORK-treated group possibly due to increased total flavonoids concentration following fermentation. Furthermore, Pb-induced high plasma creatinine levels decreased upon treatment with feeds mixed with ORK and ascorbic acid. These findings strongly indicated that feed supplementation with ORK by 45% may be more effective at ameliorating the effects of Pb-induced toxicity in tissues compared to supplementation with AA by 2%.

Author Biography

Eferhire Aganbi, Department of Biochemistry, Faculty of Science, P.M.B 1 Delta State University Abraka

Department of Biochemistry

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Published

02.10.2015

How to Cite

Aganbi, E., Avwioroko, O. J., Enabulele, E. R., Osagu, O. J., Uwandu, C. K., Ike, A., Akpede, A., & Eferusuoa, P. (2015). Amelioration of Lead-induced Toxicity in Blood, Liver and Kidney Tissues of Male Wistar Rats by Fermented Ofada Rice. Turkish Journal of Agriculture - Food Science and Technology, 3(9), 754–759. https://doi.org/10.24925/turjaf.v3i9.754-759.436

Issue

Section

Food Technologies