Affinity of Propofol to Human Serum Albumin and Cardiovascular Effects

Authors

DOI:

https://doi.org/10.24925/turjaf.v7i4.684-687.2486

Keywords:

propofol, human serum albumin, cardiovascular, Anesthesia, Hypotension

Abstract

Propofol is used in general anesthesia and sedation. İt is an lipofilic agent and metabolize to inactive form in liver then excreted in the urine. In body it is turnover changes by human serum albumin amount. >97% of propofol is bound to serum albumin. So that hypoalbunemia changes propofol effects. Free form of propopol can pass all membrans such as the blood-brain barrier and the cellular membrane of the cardiac endothelium. Propofol may cause significant myocardial depression, decrease blood pressure and cause life threatining arytmias. Changes in the ratio of free and bound forms of propofol and albumin depending on the dose and duration of administration, the effects of this ratio on cardiac profile are discussed in this study. According to the findings, it was determined that the albumin affinity of propofol decreased in all dose groups in time. Since free HSA and free propofol ratio will increase, this situation is thought to affect the cardiac profile negatively.

Author Biographies

Betül Özaltun, Department of Cardiology Faculty of Medicine, Niğde Ömer Halisdemir University, 51240

Kardiyoloji, Dr. Öğr. Üyesi

Zeliha Selamoğlu, Department of Medical Biology, Faculty of Medicine, Niğde Ömer Halisdemir University, 51240 Niğde

Biyoloji, Prof. Dr.

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Published

24.04.2019

How to Cite

Özaltun, B., & Selamoğlu, Z. (2019). Affinity of Propofol to Human Serum Albumin and Cardiovascular Effects. Turkish Journal of Agriculture - Food Science and Technology, 7(4), 684–687. https://doi.org/10.24925/turjaf.v7i4.684-687.2486

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Section

Research Paper